Global rice (Oryza sativa L.) production is impacted by a number of pests and diseases. Introducing durable genetic resistance into rice cultivars remains the most desired approach to mitigating the impacts of these pathogens. The wild relatives of rice represent largely untapped sources of novel disease resistance genes that offer new targets for breeding programs. Resistance gene analogues (RGAs) are disease resistance genes with highly conserved motifs and structural domains. It is possible to identify RGAs within plant genomes using in silico genome-wide prediction methods. This study explores the diversity and distribution of RGAs across 19 wild Oryza species. The programs RGAugury and NLRAnnotator were used to identify potential disease resistance loci within annotated Oryza genomes. The total number of RGAs identified across all genomes was 57,675. The number of RGAs identified within wild species’ ranged from 879 (O. australiensis) to 2,502 (O. punctata). Within the RGA sub-classes, the diploid O. australiensis (EE genome) had the lowest number of nucleotide-binding and leucine-rich repeat (NLRs) receptors, receptor-like proteins (RLPS), and receptor-like kinases (RLKs), whilst the allotetraploid O. punctata (BBCC) had the highest of each RGA subclass. The cultivated rice species’ O. sativa and O. glaberrima tended to have a higher number of RGAs compared to other diploid wild Oryza species, supporting suggestions that disease resistance was a selected trait during domestication. Subsequent preliminary findings indicated that many wild Oryza species possessed homologues to cloned genes conferring resistance to rice blast (Magnaporthe oryzae), bacterial blight (Xanthomonas oryzae pv. oryzae), and brown planthopper (Nilaparvata lugens). Further analyses of these may aid in identifying gene candidates that confer broad spectrum resistance against these globally-important pests and diseases. Large numbers of disease resistance loci candidates were found to be distributed along chromosome 11 in most wild Oryza species. This ongoing study will likely continue to provide insights into disease resistance across the wild relatives of rice that may aid in informing breeding strategies for durable resistant cultivars.